Nano SARMs Introduction

/Nano SARMs Introduction

Nano SARMs Introduction

Nano SARMs Introduction

NanoParticles or (Nano) are particles with sizes smaller than 1 µm (Micron0. Their extremely small size results in a high ratio of surface area to volume, resulting in faster in vivo dissolution rate, faster absorption, and increased bioavailability, compared to microparticles. Here are some key examples of how particle size differences can change the effects of a drug.

Passing through and entering cells where the active drug needs to go
Particles enter cells by a collection of processes termed endocytosis, which includes phagocytosis and pinocytosis. Phagocytosis (‘‘cell eatingʼʼ) is a means of taking up material up to 10 mm in diameter and can only be done by relatively few cell types, such as the ‘‘professionalʼʼ phagocytes, including macrophages, neutrophils, dendritic cells, and the like. Pinocytotic (‘‘cell drinkingʼʼ) uptake mechanisms can be done by all cell types, and take up submicron material and substances in solution. Consequently, microparticles can only be delivered into cells that are phagocytic, while nanoparticles can be delivered to all.

Passing through barriers that block drugs from passing through
In general, microparticles are unlikely to cross most biological barriers, rendering them useless, and so must often be delivered directly. For example, just putting a drug/hormone into a carrier such as oil or water, does not mean it will have its full intended effect, if it canʼt pass through the barriers solely because of its particle size, to the site of interest. Nanoparticles, by virtue of their smaller size, can cross such barriers, although exactly what size is necessary and what barriers can be crossed and under what conditions is often a matter of whom you ask. The ability to cross barriers can be enhanced by disease or by deliberate disruption. As examples, the endothelia in solid tumors are leakier than normal, and the blood-brain barrier can be loosened by osmotic disruption. These factors can also be used as a form of passive targeting: since injected particles can leave affected vascular beds more easily than the general circulation, they will tend to accumulate there preferentially.

Tissue Reaction
Since size will affect whether particles remain where injected, and whether or not they are phagocytosed. Most particles, if injected insufficient local concentration, will elicit an acute inflammatory response, featuring macrophages and neutrophils. After approximately 7–14 days, chronic inflammation with lymphocytes and macrophages sets in, especially if particulate material is still present. Larger particles will be engulfed individually by giant foreign body cells. Foreign body cells can also be seen with collections of smaller particles, where they can contribute to the walling off of a large area.

Less solvents Used
When creating a clear solution, chemicals, often many chemicals are added in order to dissolve the drug or substance the person is making. This typically creates a nanoparticle already, the only problem is they tend to go back
to their normal state (crystalize). So after injection, when the drug reaches a new home without solvents and the proper conditions to keep it stable, it will go back into larger particles. Which goes back to tissue reaction above. Lastly, the use of solvents and chemicals to create a stable drug often requires dangerous, cancer-causing, and painful products that you put directly into your body without any barriers to protect you from it. After a particle has decreased to a nano-sized form, you an now wash it and through different methods, capture the drug back into its original state as a solid powder form, only now its a nanoparticle and stabilized. When making a solution, there no longer is the need for chemicals or additives, just keep it sterile and preserved for future use and protected from bacteria.

Nano SarmsFigure S1 Transparency and corresponding particle size of various microemulsions containing different amounts of rh40. Notes: (A) 40%, (B) 35%, (C) 30%, (D) 15%, (E) 10%, and (F) 5%. The mixture of coix seed oil and VP16 (sample F emulsion formulation) with 5% rh40 was prepared by vigorous mechanical stirring for 30 minutes.

Summary of Nano SARMs introduction:

Nano injectable SARMs in comparison to regular injectable SARMs:

  • Nano SARMs have longer half life
  • Nano SARMS have higher potency
  • Nano SARMs consists of very little to no solvents (solvent are toxic to body)
  • Since Nano SARMs are mostly made of water they have much less post injection pain (PIP).

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